Treatment

• If you were thinking drug can settle malaria's problem, think again. Each Plasmodium species has different resistance towards drug and patients are need to take based on which resistance they have.
• Having fever, your body chills, and sweating recently? Those are malaria common symptoms and if you do have, you better take a medication treatment A.S.A.P. You will never know how serious this might be cause you might be diagnose to Malaria fever.
• Here is the list of common drugs used to treat Malaria:
• The ABCD of Malaria treatment

o A: be Aware of the risk of malaria if you are travelling to a foreign country.

o B: avoid mosquito Bites by taking appropriate measures. Reducing the number of Bites reduces the chances of getting malaria.

o C: Comply with the appropriate prophylactic drug regimen for the area you are visiting. This is vitally important since failure to comply places you at great risk. Studies have shown that there is a reduced risk of contracting malaria even if you take the wrong regimen.

o D: early Diagnosis of malaria if symptoms manifest following travel to a malarious region is vital. Malaria can be fatal but early diagnosis and treatment is usually 100% effective.

• The drug treatment of malaria depends on the type and severity of the attack. Typically, Quinine Sulphate tablets are used and the normal adult dosage is 600mg every twelve
  hours which can also be given by intravenous infusion if the illness is severe.
• Here are some extra tips for you guys:
• if suspected,A.S.A.P treatment under medical supervision
• some medicine are too expensive
  -> prophylactic(not affordable for second/third class people)
  not100% effective, need to change frequently,5 regimens(A,B,C,D)based on resistance that exist by malaria to various drug
  ->quinine(cheap but developing its resistance)
  ->arteminisin derivatives
• always remember drug can give side-effects!!
  ->Proguanil (Paludrine) can cause nausea and simple mouth ulcers.
  ->Chloroquine (Nivaquine or Avloclor) can cause nausea, temporary blurred vision and rashes.
• Patients with a history of psychiatric disturbances (including depression) should not take mefloquine as it may precipitate these conditions. It is now advised that mefloquine be started two and a half weeks before travel.
• Doxycycline does carry some risk of photosensitivation i.e. can make you prone to sunburn.
• Malarone is a relatively new treatment and is virtually free of side effects. It is licensed for use in stays of up to 28 days but there is now experience of it being taken safely for up to three months.
• No other tablets are required with mefloquine or doxycycline or Malaron.

• Why no vaccine, have to change frequent or take different medicine?
• it is because of plasmodia, not the mosquito
• plasmodia has the ability to develop resistance,which has always been challenging factor in developing vaccine and medicine treatment
• since 60s, chloroquine is the best, but throughout years,it efficiency been decline
• its plasmodia survival way->have the ability to develop resistance
• research never stop until now to tackle dis problem,but modifying drug will only increasing the drug cost->malaria affect mostly 3rd world country->unaffordable
• research never stop until now to tackle dis problem, but modifying drug will make more side-effect->different people different gene
• last few years, new drug has taken down plasmodia, but now plasmodia shows resistance to new drugs
• recently, plasmodia develop resistance to mefloquine -> see map below

Map shows area of Mefloquine-resistant Malaria