Heterogeneity in parasite virulence is one of several factors that have been proposed to contribute to the wide spectrum of disease severity in Plasmodium falciparum malaria.
Virulence factor : PfEMP1 (key adhesive ligand mediating sequestration)
Mechanism : antigenic variation process where different versions of PfEMP1 that expressed mediate adherence to different receptors on endothelial cells
Effect : avoid antibody-mediated clearance
Virulence factor : rifins (proteins of the repetitive interspersed family)
Mechanism : expressed at the surface of infected red blood cells
Effect : undergo antigenic variation
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"Plasmodium falciparum has an astonishing array of sequences and genes that play key roles in pathogenesis and immune evasion. We must understand the functions of these elements if the chronicity and unpredictable virulence of Plasmodium is to be explained."......Pls revised the sentences is not grammatically right
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